Modern lung cancer treatment is no longer just about chemotherapy. Today, we can study the DNA of the cancer to find specific changes called mutations. These mutations act like the ID card of the tumour, guiding us to the right treatment. This approach, known as biomarker testing, is the foundation for targeted therapy for lung cancer in India.
At Healius Cancer & Hematology, under the leadership of Dr. Mangesh Kamath, molecular profiling is a major focus. Dr. Kamath strongly advocates for precision medicine, ensuring every eligible patient receives a treatment plan tailored to their unique genetic signature.
Why Mutations Matter
“When we understand the tumour’s genetics, we can choose treatments that are smarter, faster-acting, and far less toxic. The goal is not just survival—it is a better quality of life.”
Certain mutations can be treated with advanced targeted therapy, often in the form of convenient tablets. These “smart drugs” work more precisely and often delay the need for traditional chemotherapy.
Common Lung Cancer Mutations in India & Their Treatments
Accessing the most effective targeted therapy for lung cancer in India starts with identifying these common mutations:
- EGFR Mutation: Found in about 20–35% of Indian patients (mostly non-smokers and women). Treated with tablets like Osimertinib or Gefitinib.
- ALK Positive: Seen in 2–5% of patients, often younger non-smokers. Tablets like Alectinib or Brigatinib can shrink tumours dramatically.
- KRAS (G12C): Once considered untreatable, new tablets like Sotorasib now offer hope for the 20–30% of Indian patients with this mutation.
- ROS1 & RET Fusions: These rare but “addicted” pathways respond exceptionally well to targeted drugs like Crizotinib or Selpercatinib.
- MET, BRAF, & NTRK: While rarer, these mutations have highly specific targeted options that offer durable control and high response rates.
Smoking and Mutations — Is There a Connection?
Yes, some mutations like EGFR and ALK are more common in non-smokers, while KRAS is more frequent in smokers. However, every patient—regardless of smoking history—should undergo molecular testing to see if they are eligible for targeted therapy for lung cancer in India.
🧪 How Do We Test for These Mutations?
At Healius Clinic, we utilize cutting-edge diagnostics:
- Tissue Biopsy: From a lung sample.
- Liquid Biopsy: A simple blood test to detect cancer DNA.
- NGS (Next-Generation Sequencing): A single test that checks for all major mutations at once.
Precision Care at Healius Cancer & Hematology
Under the guidance of Dr. Mangesh Kamath, our focus is to ensure that every patient receives the most personalized, effective, and compassionate care. By prioritizing targeted therapy for lung cancer in India, we choose treatments that are better tolerated, allowing patients to focus on healing rather than side effects.
Our commitment is simple: patient-first care, evidence-based treatment, and compassion at every step of your journey.
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