Appendix Cancer Treatment

Appendix Cancer Treatment in Bangalore

Appendix cancer is a rare type of cancer that starts in the appendix, a small pouch attached to the large intestine. While it is uncommon, it can be serious if not detected and treated early. Many patients discover appendix cancer accidentally during surgeries for other conditions, such as appendicitis. At Healius Cancer & Hematology Clinics, Bangalore, under the expertise of Dr. Mangesh Kamath, patients receive accurate diagnosis, advanced treatments, and compassionate care for appendix cancer. This blog will help you understand appendix cancer, its types, symptoms, risk factors, diagnostic procedures, and treatment options available in Bangalore. What is Appendix Cancer? Appendix cancer occurs when abnormal cells grow uncontrollably in the appendix. Depending on the type, it may be slow-growing or aggressive, potentially spreading to other organs. Unlike other gastrointestinal cancers, appendix cancer often has no obvious symptoms in its early stages. Types of Appendix Cancer Symptoms of Appendix Cancer Appendix cancer symptoms often mimic other abdominal problems, making early detection challenging: In many cases, the cancer is discovered unexpectedly during surgery for suspected appendicitis. Causes and Risk Factors While the exact cause is unknown, certain factors may increase the risk: Diagnosis of Appendix Cancer At Healius Cancer & Hematology Clinics, diagnosis involves: Appendix Cancer Treatment in Bangalore Treatment depends on the type, size, and stage of the cancer: 1. Surgery 2. Hyperthermic Intraperitoneal Chemotherapy (HIPEC) 3. Systemic Chemotherapy 4. Targeted Therapy & Immunotherapy Why Choose Healius Cancer & Hematology Clinics, Bangalore? Life After Appendix Cancer Treatment Recovery depends on the stage at which cancer is diagnosed and the type of treatment used. Many patients lead healthy lives post-treatment with proper follow-up and lifestyle adjustments: Conclusion Appendix cancer is rare, but early diagnosis and advanced treatment can significantly improve survival rates. At Healius Cancer & Hematology Clinics, Bangalore, Dr. Mangesh Kamath and his team ensure that patients receive the latest and most effective treatments with a compassionate approach. If you or your loved one is diagnosed with appendix cancer, don’t delay consultation. 📞 Call 9900613143 today to book an appointment with Dr. Mangesh Kamath and begin your journey towards recovery.

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How Breastfeeding Protects Women from Breast Cancer | Dr. Mangesh Kamath – Healius Clinics

How Breastfeeding Protects Women from Breast Cancer

How Breastfeeding Protects Women from Breast Cancer Breast cancer is one of the most common cancers affecting women worldwide. While genetics, age, and lifestyle factors play a significant role in its development, research shows that breastfeeding offers a natural and effective way to reduce the risk. Breastfeeding not only benefits the baby by providing essential nutrition and immunity but also protects the mother’s health in multiple ways. In this article, we’ll explore how breastfeeding acts as a protective shield against breast cancer, backed by medical research, expert opinions, and practical advice from Dr. Mangesh Kamath, Senior Consultant in Medical Oncology, Hemato-Oncology, and Bone Marrow Transplant at Healius Cancer & Hematology Clinics, Bangalore. Understanding Breast Cancer Breast cancer develops when abnormal cells in the breast grow uncontrollably, forming a tumor. These cells can invade surrounding tissues or spread (metastasize) to other parts of the body. Some common risk factors include: While some of these risk factors cannot be changed, lifestyle choices—including breastfeeding—can significantly reduce the likelihood of developing the disease. How Breastfeeding Reduces Breast Cancer Risk 1. Hormonal Changes During Breastfeeding When a woman breastfeeds, her body produces less estrogen and progesterone—hormones that can promote the growth of certain breast cancer cells. Reduced exposure to these hormones lowers the risk of cancer development. 2. Shedding of Breast Tissue During lactation, the breast undergoes changes to produce milk. After breastfeeding ends, the body naturally sheds breast tissue. This process can help eliminate cells with potential DNA damage, reducing the likelihood of them turning cancerous. 3. Delay in Menstrual Cycles Exclusive breastfeeding can delay the return of regular menstrual cycles (lactational amenorrhea). This reduces the total number of menstrual cycles a woman experiences in her lifetime, thus lowering lifetime hormone exposure. 4. Enhanced Differentiation of Breast Cells Breast cells mature and change during pregnancy and breastfeeding, making them more resistant to mutations that can lead to cancer. Scientific Evidence Supporting the Benefits Numerous studies have shown a link between breastfeeding and lower breast cancer risk: How Long Should You Breastfeed for Maximum Benefit? While any duration of breastfeeding provides health benefits, research suggests: Additional Health Benefits of Breastfeeding Breastfeeding’s benefits go beyond breast cancer prevention: Overcoming Common Breastfeeding Challenges Many women face difficulties in breastfeeding, such as: Tips to Overcome Challenges: When to Consult a Doctor While breastfeeding offers protection, it’s not a guarantee against breast cancer. Be alert for warning signs: If you notice any of these, seek prompt medical attention. Expert Advice from Dr. Mangesh Kamath According to Dr. Mangesh Kamath, “Breastfeeding is one of the simplest and most natural steps women can take to lower their breast cancer risk. Even partial breastfeeding can have a positive effect. However, regular breast screenings and a healthy lifestyle remain essential for overall protection.” Lifestyle Tips to Complement Breastfeeding’s Protective Effect Key Takeaways Conclusion Breastfeeding is more than a way to nourish your baby—it’s a powerful, natural strategy for protecting your long-term health. Backed by scientific evidence, it plays a significant role in reducing breast cancer risk. If you have questions about breast health, cancer prevention, or need guidance on breastfeeding challenges, visit Healius Cancer & Hematology Clinics in Bangalore and consult Dr. Mangesh Kamath for personalized care.

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Lung Cancer Treatment in Bangalore | Dr. Mangesh Kamath – Healius Clinics

Lung Cancer Treatment in Bangalore | Dr. Mangesh Kamath – Healius Clinics

Lung cancer is one of the most common cancers worldwide, affecting both men and women. Early detection and effective treatment can significantly improve survival rates. At Healius Cancer & Hematology Clinics, we provide advanced lung cancer care under the expertise of Dr. Mangesh Kamath, one of Bangalore’s leading cancer specialists. What is Lung Cancer?Lung cancer begins in the lungs and can spread to other parts of the body if not treated promptly. It is typically classified into two main types: Causes and Risk Factors Symptoms of Lung Cancer Diagnosis at Healius ClinicsWe use advanced diagnostic tools such as CT scans, PET scans, bronchoscopy, and biopsy to ensure accurate detection. Treatment Options At Healius Cancer & Hematology Clinics, we provide a comprehensive approach including: Why Choose Dr. Mangesh Kamath? Contact Details📞 Call: 9900613143📍 Healius Cancer & Hematology Clinics, Bangalore ConclusionIf you or a loved one is facing lung cancer, early consultation can make all the difference. Get expert, compassionate care from Dr. Mangesh Kamath at Healius Cancer & Hematology Clinics.

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Chronic Lymphocytic Leukaemia (CLL): The Slow but Manageable Blood Cancer

Chronic Lymphocytic Leukaemia (CLL): The Slow but Manageable Blood Cancer 🩸 What is CLL? Chronic Lymphocytic Leukaemia (CLL) is a type of blood and bone marrow cancer where the body makes too many abnormal white blood cells called lymphocytes. These cells look normal but do not work properly to fight infections. Over time, they build up in the blood, bone marrow, and lymph nodes, pushing out the healthy cells. Unlike aggressive leukaemia’s like AML or ALL, CLL is slow-growing. Many people live with CLL for years before needing treatment. In fact, some people may never need active therapy and are only monitored. 🌍 How Common is CLL? ⚠️ Risk Factors and Causes The exact cause of CLL is not known. But certain risk factors make it more likely: 👉 CLL is not contagious and is not caused by lifestyle or diet. 🔍 Common Symptoms of CLL Many patients are diagnosed during a routine blood test without any symptoms. When present, symptoms may include: 🧪 How is CLL Diagnosed? 🎯 Risk Stratification in CLL CLL does not behave the same way in every patient. Some people live for decades without treatment, while others need immediate therapy. Risk stratification helps doctors decide the best approach. 🔹 Risk Stratification Systems in CLL: 👉 These risk groups guide whether a patient should be on watch & wait, given tablets, or considered for advanced therapies. 💊 Treatment Options for CLL 1. Watchful Waiting (Active Surveillance) 2. Targeted Therapy 3. Chemo-Immunotherapy 4. Monoclonal Antibodies 5. Stem Cell Transplant 🚀 Recent Advances in CLL Treatment 📊 CLL vs Other Leukaemias – A Simple Comparison Feature CLL CML ALL AML Progression Slow (chronic) Slow (chronic) Fast (acute) Fast (acute) Typical Age >60 yrs 40–60 yrs Children & young adults Mostly adults, esp. >60 yrs Cells Involved Lymphocytes Myeloid cells Immature lymphoblasts Immature myeloid cells Symptoms Often none early; enlarged nodes, fatigue Fatigue, splenomegaly, high WBC Fever, bleeding, bone pain Fatigue, bleeding, infections Treatment Watchful waiting, targeted therapy, antibodies TKIs (Imatinib, etc.), sometimes transplant Chemotherapy, targeted therapy, immunotherapy Intensive chemo, transplant Curability Usually controlled for years; remission possible Excellent long-term control with TKIs High cure rates, esp. in children Curable with aggressive therapy but relapse risk exists 🌈 Living with CLL: A Message of Reassurance CLL is often called a “chronic” cancer, meaning it can be controlled long-term. Many patients live a normal lifespan, especially with today’s advanced therapies. For many, CLL becomes a condition that is managed like diabetes or hypertension rather than a life-ending disease. Regular follow-up, timely treatment when needed, and support from family and healthcare teams make a huge difference. ❤️ Final Thoughts From Healius Cancer and Haematology Clinics At Healius Cancer and Haematology Clinics, we understand the anxiety that comes with a diagnosis of CLL. The good news is that treatment has advanced tremendously—from chemotherapy to highly effective targeted therapies that give excellent quality of life. Under the guidance of Dr. Mangesh Kamath, our team provides: 👉 Remember: CLL is not the end. With modern science, it is a journey that can be lived with hope, strength, and dignity.

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Breaking Down Chronic Myeloid Leukaemia: Your Guide to Understanding and Beating the Disease

Chronic Myeloid Leukaemia, commonly known as CML, is a type of blood cancer that starts in the bone marrow—the soft tissue inside bones where blood cells are made. CML mainly affects a group of white blood cells called myeloid cells, which normally help fight infections. But in CML, these cells grow uncontrollably and do not function as they should. Global and Indian Prevalence According to the GLOBOCAN 2020 data, leukaemia accounts for over 474,000 new cases and 311,000 deaths globally each year. Among these, CML represents about 15–20% of adult leukaemia cases. In India, CML is the most common adult leukaemia, making up around 30–60% of adult cases depending on the region. It is much rarer in children, but when it occurs, it usually behaves more aggressively than in adults. What Causes CML? CML is not inherited. It happens due to a genetic change in the blood-forming cells. Almost all people with CML have a specific genetic abnormality called the Philadelphia chromosome, which creates a faulty gene called BCR-ABL1. This gene tells the body to produce a protein that makes abnormal cells grow too fast. Risk Factors CML does not usually have clear lifestyle-related risk factors like smoking or diet. However, a few things may slightly increase the risk: It is important to know that for most people, there is no clear reason why they develop CML. Signs and Symptoms In the early (chronic) phase, many people do not feel sick and are diagnosed during routine blood tests. As the disease progresses, symptoms may appear, such as: How is CML Diagnosed? A Complete Blood Count (CBC) is usually the first clue. If the white blood cell count is abnormally high, further tests like bone marrow biopsy, Philadelphia chromosome testing, or BCR-ABL1 gene testing are done to confirm the diagnosis. Phases of CML CML progresses in three phases: Risk Stratification in CML: Why It Matters When someone is diagnosed with CML, doctors do not just look at the blood counts and genes—they also try to estimate how aggressive the disease might be. This process is called risk stratification. What Are the Risk Stratification Scores in CML? Doctors use special scoring systems at the time of diagnosis to estimate how fast the CML may progress. This helps decide the intensity of treatment and monitoring. The most used risk scores include: 🔹 Sokal Score One of the oldest and most widely used tools. It considers: Patients are classified into: 🔹 Hasford Score (Euro Score) An update to the Sokal score, it includes: 🔹 EUTOS Score A simpler model that mainly uses: This score helps predict early response to treatment, especially in patients receiving tyrosine kinase inhibitors (TKIs). 🔹 ELTS Score (EUTOS Long-Term Survival) This newer score focuses on predicting long-term survival, rather than just early response. It includes: It is currently one of the most preferred risk tools for newly diagnosed CML patients. Why Should You Care About These Scores? While the names and numbers may sound technical, these scores help your doctor: Most importantly, they allow your care team to personalize your treatment plan to give you the best possible outcome. Treatment Options Thanks to medical advances, CML is now considered a manageable chronic condition, especially when diagnosed in the chronic phase. 1. Targeted Therapy (TKIs) The mainstay treatment for CML is Tyrosine Kinase Inhibitors (TKIs). These drugs block the BCR-ABL1 protein and stop the cancer from growing. Common TKIs include: Most patients take a TKI as tablets daily, often for life, but some may qualify for treatment-free remission if the disease stays under control for years. 2. Bone Marrow or Stem Cell Transplant This is usually reserved for patients who do not respond to TKIs or are in advanced stages. It is a more intense treatment with potential risks, but it can be curative. 3. Chemotherapy or Immunotherapy Traditional chemotherapy is rarely needed, but interferon-alpha, a type of immunotherapy, was used before TKIs and may still help in selected patients. Newer immunotherapy options are still under research for CML, including CAR T-cell therapy, but are not yet standard treatment. Recent Advances in Treatment Living with CML Can CML Be Prevented? Unfortunately, since the exact cause of CML is unknown in most cases, there are no proven preventive measures. However: can help in early detection and timely treatment. Final Thoughts At Healius Cancer and Haematology Clinics, we understand that a diagnosis of Chronic Myeloid Leukaemia (CML) can be overwhelming—not just for the patient, but for the entire family. But the good news is that CML is one of the most successfully treated forms of leukaemia today. With timely diagnosis, targeted therapies, and close monitoring, it is possible to lead a normal, healthy, and productive life. Under the expert care of Dr. Mangesh Kamath, Medical Oncologist and Haemato-Oncologist, we provide personalized, evidence-based treatment for each patient, including access to the latest in diagnostics, targeted therapy, molecular monitoring, and comprehensive support services. We are committed to walking with you at every step—from diagnosis through treatment and beyond—ensuring that you and your loved ones feel informed, supported, and empowered. If you or someone you know has been diagnosed with CML, remember:You are not alone. You are in trusted hands.

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Acute Myeloid Leukaemia: Understanding the Disease of the Blood

Among the body fluids blood plays a major role in vital functioning of our body. It carries oxygen, nutrients to all organs and acts as a scavenger by carrying waste products to respective organs for further processing where they are removed from the body. The blood consists of four main components which are red blood cells, white blood cells, platelets, and plasma. These components are produced in the bone marrow which is the spongy tissue inside your bones. The myeloid stem cells originated from the bone marrow further differentiates into white blood cells, red cells, and platelets. When there is abnormal or uncontrolled production of these undifferentiated myeloid cells (called myeloblast) cause fast growing cancer of the bone marrow and blood known as Acute Myeloid Leukaemia. What Causes Acute Myeloid Leukaemia (AML)?  AML is caused due to the changes that occur in our genes in the DNA of the Myeloid cells. Yet it is still unknown as to what triggers the change. However, there are few risk factors that increases the risk of AML which includes: How Common Is AML? (Global & Indian Statistics) AML is more common in older adults, with most cases diagnosed after age 65. According to GLOBOCAN 2022 (a global cancer database):   What Are the Symptoms of AML?   Since AML affects blood cell production, symptoms often include:   These symptoms can appear suddenly and worsen quickly, so seeing a doctor early is crucial.   How Do Doctors Determine the Severity of AML? (Risk Stratification) Not all AML cases are the same—some are more aggressive than others. Doctors classify AML into low, intermediate, and high-risk categories based on:   Why Does Risk Stratification Matter? This personalized approach helps doctors choose the best treatment while avoiding unnecessary side effects.   What Are the Treatment Options for AML? 1. Chemotherapy The standard first treatment is “7+3″ chemotherapy—a combination of two drugs given over 7 days. This kills leukaemia cells but also affects healthy cells, causing side effects like hair loss, nausea, and low blood counts.   2. Targeted Therapy  Newer drugs specifically attack cancer cells without harming normal cells as much. Examples include:   3. Stem Cell Transplant For high-risk patients, a bone marrow transplant (from a donor) may be the best chance for a cure. However, it is a complex procedure with risks like infections and graft-versus-host disease (where donor cells attack the body).   4. Supportive Care   Since AML weakens the immune system, patients often need:   5. Special Case: APL (A Highly Curable Subtype)   A rare form of AML called acute promyelocytic leukemia (APL) is treated differently—with vitamin A-based drugs (ATRA) and arsenic trioxide, leading to cure rates above 90%.   Hope for the Future   While AML remains a serious disease, advances in genetic testing, targeted therapies, and immunotherapy are improving survival rates. Early diagnosis and access to specialized care are critical—especially in countries like India, where awareness and healthcare access vary widely.   If you or a loved one experience persistent fatigue, infections, or unusual bleeding, consult a doctor promptly. With the right treatment, many AML patients can achieve remission and lead fulfilling lives.

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Get expert care for head and neck cancer at Healius Clinics, Bangalore. Consult Dr. Mangesh Kamath for advanced, affordable treatment.

Head and Neck Cancer

Head and neck cancer refers to a diverse group of malignant tumors that develop in or around the throat, larynx, nose, sinuses, and mouth. It is one of the most common types of cancer in India, and with early detection and the right treatment, it can be effectively managed. This comprehensive guide will help you understand the symptoms, causes, treatment options, and how Healius Cancer & Hematology Clinics, under the leadership of Dr. Mangesh Kamath, offer the best care for head and neck cancer in Bangalore. Head and neck cancers usually originate in the squamous cells that line the moist mucosal surfaces inside the head and neck, such as the mouth, nose, and throat. These are collectively called squamous cell carcinomas. Less commonly, cancer can form in the salivary glands, lymph nodes, or other structures in the head and neck region. Understanding Head and Neck Cancer These cancers are categorized based on the region they affect: Symptoms of Head and Neck Cancer Early detection is vital. The symptoms vary depending on the cancer’s location but may include: If these symptoms persist for more than two weeks, it is critical to seek medical attention. Causes and Risk Factors Several factors increase the risk of developing head and neck cancer: Diagnosis of Head and Neck Cancer Accurate diagnosis is the cornerstone of effective treatment. At Healius Cancer & Hematology Clinics, we use a combination of modern diagnostic tools: Meet Dr. Mangesh Kamath: A Leader in Cancer Treatment Dr. Mangesh Kamath is a seasoned and compassionate medical oncologist with extensive experience in treating complex cancer cases, including head and neck, lung, breast, ovary, stomach, colorectal, lymphoma, and myeloma. He is known for his patient-centric approach, in-depth knowledge, and commitment to offering the latest treatment modalities. Patients from across Karnataka and beyond seek his guidance at Healius Cancer & Hematology Clinics, one of the best cancer treatment centers in Bangalore. Treatment Options for Head and Neck Cancer Treatment depends on the cancer’s location, stage, and the patient’s overall health. At Healius, we offer: Multidisciplinary Approach at Healius Our head and neck cancer treatment involves collaboration among: This holistic approach ensures comprehensive care and better outcomes. Patient-Centric Care What sets Healius Cancer & Hematology Clinics apart is our focus on: Prevention Tips and Awareness Success Stories and Testimonials Patients treated for head and neck cancer at Healius have experienced remarkable recoveries. Many have returned to normal life, thanks to timely intervention and personalized care. Here’s what one of our patients shared: “I was scared when I first got diagnosed with tongue cancer. But under Dr. Mangesh Kamath’s guidance, the journey was full of hope. The entire team at Healius treated me with utmost care and professionalism. I’m now cancer-free and living life to the fullest.” Integration with Other Cancer Care At Healius, we don’t just specialize in head and neck cancer. Our expertise extends to: This cross-functional expertise ensures we understand metastatic behavior and secondary tumor formation that may involve multiple body parts. When to See a Specialist If you have symptoms like persistent mouth sores, voice changes, or neck swelling, it’s crucial not to ignore them. Early diagnosis increases the chances of complete recovery. Dr. Mangesh Kamath is available for consultation at Healius Cancer & Hematology Clinics in Bangalore. Book Your Consultation Don’t wait until it’s too late. If you or a loved one is experiencing any symptoms of head and neck cancer or seeking a second opinion, reach out to us: Phone: +91 99006 13143Website: healiuscancerhematology.comLocation: KR Road, Bangalore Conclusion Head and neck cancers are serious but treatable diseases, especially when caught early and managed with a strategic, multidisciplinary approach. With Dr. Mangesh Kamath’s expertise and the advanced infrastructure of Healius Cancer & Hematology Clinics, patients in Bangalore and beyond can access world-class care without the prohibitive costs often associated with cancer treatment. Whether you’re dealing with head and neck cancer, lung, breast, ovary, stomach, colorectal, lymphoma, or myeloma, Healius is your trusted partner in the fight against cancer. Call +91 9900613143 today to book an appointment and take the first step toward recovery.

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Acute Lymphoblastic Leukemia (ALL): A Comprehensive Guide for Patients and Caregivers

Acute Lymphoblastic Leukemia (ALL): A Comprehensive Guide for Patients and Caregivers Introduction: Understanding ALL Acute Lymphoblastic Leukaemia (ALL), also called acute lymphocytic leukaemia, is a rapidly progressing cancer of the blood and bone marrow. It affects the lymphoid lineage of white blood cells, particularly immature lymphoblasts. These abnormal cells multiply uncontrollably, crowding out normal blood cells and impairing immune function. ALL primarily occurs in children but also affects adults, with varying treatment responses and outcomes between age groups. Prevalence and Global Burden According to the GLOBOCAN 2022 estimates: Worldwide incidence: ~64,000 new ALL cases annually Children: ALL is the most common paediatric cancer, accounting for about 75–80% of all childhood leukaemia cases, with peak incidence between ages 2 and 5. Adults: Less common but more aggressive, representing ~20% of adult leukaemia cases, with poorer prognosis compared to paediatric ALL. In India, ALL contributes significantly to childhood cancer burden. The ICMR-NCDIR data shows an annual incidence of 4–5 cases per 100,000 children, with improving survival rates in urban centres due to better access to specialized care. How Does ALL Develop? ALL begins in the bone marrow, where early lymphoid progenitor cells (typically B or T cell lineage) undergo genetic mutations, disrupting normal differentiation and triggering uncontrolled proliferation. As these immature lymphoblasts multiply, they spill into the bloodstream and infiltrate organs like the liver, spleen, and central nervous system (CNS), causing systemic symptoms and complications. Causes and Risk Factors The exact cause is often unknown, but multiple factors can contribute: Genetic predisposition: Down syndrome, Li-Fraumeni syndrome, and other hereditary syndromes Prenatal chromosomal changes: Like TEL-AML1 fusion Radiation or chemical exposure: High-dose radiation or previous chemotherapy Infections and immune system factors: Delayed infections during childhood might alter immune regulation Family history: Siblings with ALL carry a slightly increased risk Genomic Landscape of ALL ALL is a genomically diverse disease, and molecular subtyping is critical for personalized treatment. Key genetic abnormalities include: 🔹 B-Cell ALL Genomics Hyperdiploidy: >50 chromosomes in cells; good prognosis in children ETV6-RUNX1 fusion: Favourable outcome Ph-positive (BCR-ABL1): Common in adults; poor prognosis unless treated with tyrosine kinase inhibitors (TKIs) Ph-like ALL: BCR-ABL1-like gene expression with kinase-activating lesions; high-risk 🔹 T-Cell ALL Genomics NOTCH1 mutations: Common, often targetable TAL1, LMO1/2 alterations Early T-precursor (ETP) ALL: Aggressive subtype with high relapse risk Comprehensive genomic profiling (e.g., using next-generation sequencing, FISH, PCR) guides risk stratification and targeted therapy selection. Symptoms of ALL Symptoms are often non-specific and may mimic common infections: Fatigue, pallor (due to anaemia) Fever, frequent infections (due to neutropenia) Easy bruising, bleeding (from low platelets) Bone or joint pain Swollen lymph nodes, liver, or spleen CNS symptoms (in advanced cases): headache, vomiting, visual changes Diagnosis Accurate diagnosis involves: Complete blood count (CBC): Shows blasts, anaemia, and low platelets Peripheral smear and bone marrow aspiration/biopsy: Confirm diagnosis and estimate blast percentage Immunophenotyping (flow cytometry): Classifies B vs T cell ALL Cytogenetics and molecular tests: Identify high-risk genetic features Lumbar puncture: Checks for CNS involvement Treatment Approaches Treatment for ALL is intensive and often spans 2–3 years, especially in children. Chemotherapy Induction phase: Eliminates most leukemic cells (first 4–6 weeks) Consolidation: Prevents regrowth using high-dose chemo Maintenance: Low-intensity therapy over 1–2 years Drugs include vincristine, corticosteroids, L-asparaginase, anthracyclines, methotrexate, cytarabine Targeted Therapy Imatinib, Dasatinib: For BCR-ABL1 (Ph-positive) ALL Ruxolitinib: In Ph-like ALL with JAK mutations Venetoclax: Investigated in relapsed cases NOTCH1 pathway inhibitors: In T-cell ALL (clinical trials) Immunotherapy Blinatumomab: BiTE antibody that links CD3 (T-cells) and CD19 (B-cells) Inotuzumab ozogamicin: Anti-CD22 antibody-drug conjugate CAR T-cell therapy (e.g., tisagenlecleucel): For relapsed/refractory B-cell ALL in children and young adults Stem Cell Transplant (HSCT) Recommended for high-risk patients or those who relapse. Best outcomes when done in first remission with a matched donor. Recent Advances Minimal Residual Disease (MRD) monitoring using flow cytometry or PCR helps detect low levels of leukaemia post-treatment Genomics-guided therapy: Enables better risk-adapted treatment Shorter, more effective chemo protocols: Especially in paediatric ALL New trials: Combining targeted therapy with standard chemo for improved outcomes Prevention and Lifestyle During & After Treatment Though ALL can’t be fully prevented, minimizing risk factors (e.g., radiation exposure, healthy pregnancy) is beneficial. During treatment: Eat a neutropenic-safe diet: well-cooked food, avoid raw meats Hydrate well and manage nausea, mucositis, and constipation Maintain good oral hygiene Prevent infections: regular handwashing, avoid crowds Vaccinations may be paused temporarily Gentle exercise and physical therapy to reduce fatigue After treatment: Annual follow-ups with bone marrow and MRD tests Monitor for late effects: cardiac toxicity, infertility, secondary cancers Balanced diet rich in protein, iron, and antioxidants Emotional recovery and school/work reintegration support Psychological and Emotional Impact Living with or caring for someone with ALL can be emotionally taxing. Children especially need a strong support system to cope with: Fear of relapse Isolation during long hospital stays Anxiety around chemotherapy and side effects Academic or social setbacks Support options include: Paediatric psycho-oncologists Family counselling and caregiver support groups Art/music/play therapy Survivorship programs Conclusion: Hope with Healing At Healius Cancer and Haematology Clinics, under the expert guidance of Dr. Mangesh Kamath and his team, we emphasize personalized, evidence-based care for ALL patients—tailoring treatment to each patient’s genetic profile, age, and risk status. With significant advancements in therapy, especially for children, survival rates have dramatically improved, and the future of ALL treatment continues to get brighter. Remember: Early diagnosis, genomic testing, adherence to treatment, and emotional support are the cornerstones of overcoming ALL. Book an Appointment

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Understanding Glioblastoma: Challenges, Treatment Advances, and the Road Ahead

Understanding Sarcoma: A Rare but Treatable Cancer – With Expert Care at Healius Cancer and Haematology Clinics At Healius Cancer & Hematology Clinics, we believe that every patient deserves global-standard care—right here at home. Here’s how we are making that possible: Multidisciplinary Neuro-Oncology Team Our team includes oncologists, neurosurgeons, radiologists, pathologists, and palliative care specialists who work together to design personalized treatment plans. Access to Precision Medicine We offer molecular tumor profiling to identify genetic mutations and match patients with targeted therapy or clinical trials where applicable. Advanced Diagnostics Healius provides access to high-resolution MRI, PET-CT, and biopsy with histopathology, enabling accurate diagnosis and monitoring. Patient-Centered Support We go beyond medical treatment with support services like: Psychological counseling Nutrition planning Caregiver guidance Rehabilitation and follow-up care Looking Ahead: Hope Through Research and Compassionate Care While glioblastoma remains one of the most difficult cancers to treat, innovation, early diagnosis, and integrative care are key to improving outcomes. We remain dedicated to bridging the gap between global advances and accessible, affordable cancer care in Bangalore. If You or a Loved One is Facing a Brain Tumor Diagnosis Reach out to Healius Cancer & Hematology Clinics for expert consultation, second opinions, and access to advanced glioblastoma care. 📞 Call us today : +91 9900613143 Or🌐 Visit: www.healiuscancerhematology.com to book your appointment. Book an Appointment

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Understanding Sarcoma: A Rare but Treatable Cancer – With Expert Care at Healius Cancer and Haematology Clinics

Understanding Sarcoma: A Rare but Treatable Cancer – With Expert Care at Healius Cancer and Haematology Clinics Sarcoma is a rare group of cancers that begin in the bones or soft tissues such as fat, muscle, nerves, blood vessels, or connective tissues. Unlike more common cancers, sarcomas can occur anywhere in the body and are known for their diverse subtypes. They are broadly classified into bone sarcomas (like osteosarcoma and Ewing’s sarcoma) and soft tissue sarcomas (such as liposarcoma, leiomyosarcoma, and synovial sarcoma). 📊 Prevalence in India Sarcomas account for less than 1% of all adult cancers and around 15% of all childhood cancers. In India, the burden is slowly being recognized, particularly among the paediatric and young adult population. Due to their rarity, sarcomas are often misdiagnosed or diagnosed late, making expert multidisciplinary care crucial. 🧬 Causes and Hereditary Factors While the exact cause of sarcoma remains unknown in most cases, several risk factors have been identified: Genetic syndromes like Li-Fraumeni syndrome, Neurofibromatosis type 1, and hereditary retinoblastoma increase the risk. Radiation exposure from prior cancer treatment. Certain chemical exposures and chronic swelling (lymphedema). Some cases emerge without any known risk factors. 👶 Impact on Children Sarcomas like rhabdomyosarcoma and Ewing’s sarcoma are among the most common childhood cancers. These diagnoses can deeply affect the child’s physical growth, emotional development, and social interactions, making compassionate and comprehensive care essential. 👶 Impact on Children – Special Focus on Neural-Origin Sarcomas Sarcomas such as rhabdomyosarcoma, Ewing’s sarcoma, and osteosarcoma are among the most common in children. However, a smaller subset of paediatric sarcomas arises from the neural tissue, such as Malignant Peripheral Nerve Sheath Tumours (MPNST). These neural-origin sarcomas are often linked to genetic conditions like Neurofibromatosis type 1 (NF1) and may present as rapidly enlarging, deep-seated, and painful masses. Their aggressive behavior and potential to affect vital nerve structures make early diagnosis and expert management crucial. At Healius Cancer and Haematology Clinics, children with such rare tumours receive specialized, age-appropriate care under the guidance of Dr. Mangesh Kamath, with a focus on: Preserving neurological function Ensuring optimal tumour control Supporting the child’s psychological and developmental health Our team works closely with paediatric surgeons, neurologists, psychologists, and rehabilitation experts to deliver holistic care and improve long-term quality of life. 💊 Treatment Options at Healius Cancer and Haematology Clinics Under the expert guidance of Dr. Mangesh Kamath, a renowned medical oncologist, sarcoma patients at Healius receive personalized and evidence-based treatment plans that may include: Surgery to remove the tumor with maximum tissue preservation Radiation therapy for local control, especially when surgery isn’t feasible Chemotherapy for aggressive or metastatic disease Targeted therapy and immunotherapy in select cases based on genetic profiling Each patient benefits from a multidisciplinary tumor board discussion, ensuring optimal treatment planning and sequencing. ❤️‍🩹 Coping With Treatment and Beyond Sarcoma treatment can be intense and long-term, affecting both the patient and their family. At Healius, our holistic approach includes: Psychological counseling and emotional support Nutritional guidance to aid recovery and manage treatment side effects Physiotherapy and rehabilitation to restore function and mobility Survivorship care plans for long-term monitoring and quality of life We walk hand-in-hand with caregivers, providing education, support groups, and respite care resources. 🏥 Why Choose Healius Cancer and Haematology Clinics? At Healius, we believe every sarcoma patient deserves precision medicine with a human touch. Under the leadership of Dr. Mangesh Kamath, we combine advanced oncology with compassionate care. From diagnosis to survivorship, we ensure that no patient feels alone in their journey. Healius – where expertise meets empathy. Book an Appointment

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